孙世仁，男， 1971 年 10 月生，甘肃籍，现任空军军医大学第一附属医院（西京医院）肾脏内科主任，博士研究生导师，医学博士，主任医师、教授。现担任中国医师协会整合肾脏病学分会主任委员，中国医师协会肾脏内科分会常委，解放军肾脏病学会副主任委员，陕西省医师协会肾脏内科分会会长；陕西省肾脏病学会候任主任委员。担任《 J Am Soc Nephrol （中文版）》、《 Am J Kidney Dis 中文版）》、《中华肾脏病杂志》、《中华肾病研究电子杂志》、《临床军医杂志》编委。以第一负责人主持国家自然科学基金 4 项，十二五科技支撑计划分课题，科技部“ 973 计划”项目学术骨干 , 陕西省科技创新领军人才，空军高层次科技人才，第四军医大学“精英人才”计划项目资助，以第一完成人获陕西省科技进步一等奖 1 项，军队医疗成果三等奖 3 项、国家发明专利 2 项 ; 以第一 / 通信作者在《 Kidney Int 》、《 Intensive Care Med 》、《 Nephrol Dial Transplant 》、《 Am J Nephrol 》等杂志发表 SCI 论文 50 余篇，影响因子 >10 分论文 2 篇， 5 至 10 分的 8 篇，多篇论文获国际权威专家发表述评给予高度评价，部分结果写入德国、法国等多个国际临床实践指南。作为主要执笔人参与撰写肾脏病学和血液净化领域中国指南或专家共识 6 部。 主编学术著作 5 部，副主编教材 3 部。擅长狼疮性肾炎、系统性淀粉样变性、 ANCA 相关性血管炎、 IgA 肾病、难治性肾病综合征等原发及继发性肾小球疾病的中西医结合诊治和各种血液净化技术（ CRRT ，血液透析，腹膜透析）。

学习经历：

1999/09-2002/06第四军医大学硕士

2006/09-2009/06第四军医大学博士

2013/09-2014/06美国Mayo Clinic肾脏病与高血压科访问学者

工作经历：

2003/09-2006/08西京医院肾脏内科主治医师、讲师

2009/09-2016/08西京医院肾脏内科副主任医师、副教授

2016/09-至今西京医院肾脏内科主任医师、教授

2010.09-至今西京医院肾脏内科科室主任

近些年发表的主要文章：

1.Sun S#, Ning X#, Zhang Y#, Lu Y, Nie Y, Han S, Liu L, Du R, Xia L, He L, Fan D.Hypoxia-induciblefactor-1alpha induces Twist expression in tubular epithelial cells subjected to hypoxia, leading to epithelial-to-mesenchymal transition. Kidney Int. 2009;75(12):1278-1287.

2.Bai M, Zhang L, Fu B, Bai J, Zhang Y, Cai G, Bai X, Feng Z, Sun S*, Chen X*.IL-17A improves the efficacy of mesenchymal stem cells in ischemic-reperfusion renal injury by increasing Treg percentages by the COX-2/PGE2 pathway.Kidney Int. 2018;93(4):814-825. (*通讯作者).

3.Zhang L#, Liu L#, Bai M#, Liu M, Wei L, Yang Z, Qian Q, Ning X*, Sun S*. Hypoxia-induced HE4 in tubular epithelial cells promotes extracellular matrix accumulation and renal fibrosis via NF-κB. FASEB J. 2020;34(2):2554-2567.(*通讯作者)

4.Liu T, Liu L, Liu M, Du R, Dang Y, Bai M, Zhang L, Ma F, Yang X, Ning X*, Sun S*. MicroRNA-493 targets STMN-1 and promotes hypoxia-induced epithelial cell cycle arrest in G2/M and renal fibrosis. FASEB J. 2019;33(2):1565-1577. (*通讯作者).

5.Liu L, Zhang P, Bai M, He L, Zhang L, Liu T, Yang Z, Duan M, Liu M, Liu B, Du R, Qian Q*, Sun S*.p53 Upregulated by HIF-1α Promotes Hypoxia-induced G2/M Arrest and Renal Fibrosis in vitro and in vivo. J Mol Cell Biol. 2019;11(5):371-382. (*通讯作者).

6.Sun S#, Li H#, Chen J, Qian Q.Lactic Acid: No Longer an Inert and End-Product of Glycolysis. Physiology (Bethesda). 2017;32(6):453-463.

7.Sun S#, Sun W#, Xia L#, Liu L#, Du R, He L, Li R, Wang H, Huang C. The T-box transcription factor Brachyury promotes renal interstitial fibrosis by repressing E-cadherin expression.Cell Commun Signal. 2014;12(1):76.

8.Sun S#, Du R#, Xia L#, Sun W, Zhai Y, Yu Y, Zhao A, Huang C, Ning X, Wang H. Twist Is a New Prognostic Marker for Renal Survival in Patients with Chronic Kidney Disease. Am J Nephrol . 2012;35(2):141-151.

9.Sun S#, Ning X#, Zhai Y#, Du R, Lu Y, He L, Li R, Wu W, Sun W, Wang H. Egr-1 mediates chronic hypoxia-induced renal interstitial fibrosis via the PKC/ERK pathway. Am J Nephrol. 2014;39(5):436-48.

10.Sun S#, Zhao A#, Li R, Du R, He L, Sun W, Wang H, Huang C.CD147 renal expression as a biomarker for progressive IgAN. J Nephrol. 2015;28(3):307-14.

11.Sun S#, Du R#, Gao J#, Ning X, Xie H, Lin X, Liu J, Fan D. Expression and clinical significance of Notch receptors in human renal cell carcinoma.Pathology. 2009;41(4):335-41.

12.Sun S#, Ning X#, Liu J, Liu L, Chen Y, Han S, Zhang Y, Liang J, Wu K, Fan D. Overexpressed CacyBP/SIP leads to the suppression of growth in renal cell carcinoma. Biochem Biophys Res Commun. 2007;356(4):864-71

13.Sun S, He L, Bai M, Liu H, Li Y, Li L, Yu Y, Shou M, Jing R, Zhao L, Huang C, Wang H. High-volume hemofiltration plus hemoperfusion for hyperlipidemic severe acute pancreatitis: a controlled pilot study. Ann Saudi Med. 2015; 35(5):352-8.

14.Ning X, Zhang K, Wu Q, Liu M, Sun S*.Emerging role of Twist1 in fibrotic diseases. J Cell Mol Med. 2018;22(3):1383-1391. (*通讯作者)

15.Yang Z, Zhang Y, Sun S*. Deciphering the SUMO code in the kidney. J Cell Mol Med. 2019;23(2):711-719. (*通讯作者)

16.Liu M, Liu T, Shang P, Zhang Y, Liu L, Liu T, Sun S*.Acetyl-11-keto-β-boswellic acid ameliorates renal interstitial fibrosis via Klotho/TGF-β/Smad signalling pathway. J Cell Mol Med. 2018;22(10):4997-5007. (*通讯作者)

17.Yang X, Bai M, Ning X, Ma F, Liu L, Liu T, Liu M, Wang H, Sun S*. The associations of Bmi-1 with progression of glomerular chronic kidney disease. Clin Nephrol. 2018 Feb;89(2):93-103. (*通讯作者)

18.Liu B, Wang Y, Bai M, Wang D, Zhao J, Zhang M, Sun S*. Cyclophosphamide + Thalidomide + Dexamethasone Versus Melphalan + Dexamethasone for the Treatment of Amyloid Light-chain Amyloidosis With Kidney Involvement: A Retrospective Study in Chinese Patients. Clin Ther. 2019;41 (6):1186-1198. (*通讯作者)

19.Liu M, Liu L, Bai M, Zhang L, Ma F, Yang X, Sun S*.Hypoxia-induced activation of Twist/miR-214/E-cadherin axis promotes renal tubular epithelial cell mesenchymal transition and renal fibrosis. Biochem Biophys Res Commun. 2018 15;495(3):2324-2330. (*通讯作者)

20.Du R, Xia L, Ning X, Liu L, Sun W, Huang C, Wang H, Sun S*. Hypoxia-induced Bmi1 promotes renal tubular epithelial cell-mesenchymal transition and renal fibrosis via PI3K/Akt signal. Mol Biol Cell. 2014 Sep 1;25(17):2650-9. (*通讯作者)

21.Du R, Zhao L, Xia L, Liu L, Sun W, Zhao A, Yu Y, Han H, Sun S*. Association of URG11 and Twist with clinical pathological characteristics and prognosis in patients with IgA nephropathy. Nephrol Dial Transplant. 2013;28(9):2268-76. (*通讯作者)

22.Du R, Huang C, Bi Q, Zhai Y, Xia L, Liu J, Sun S*, Fan D. URG11 mediates hypoxia-induced epithelial-to-mesenchymal transition by modulation of E-cadherin and beta-catenin. Biochem Biophys Res Commun. 2010:391(1):135-41.（*通讯作者）

23.Ma F, Bai M, Li Y, Yu Y, Liu Y, Zhou M, Li L, Jing R, Zhao L, He L, Li R, Huang C, Wang H, Sun S*. Continuous Venovenous Hemofiltration (CVVH) Versus Conventional Treatment for Acute Severe Hypernatremia in Critically Ill Patients: A Retrospective Study. Shock. 2015 :44(5):445-51. (*通讯作者）

24.Bai M, Yu Y, Huang C, Liu Y, Zhou M, Li Y, Ma F, Jing R, Zhao L, Li L, Wang P, He L, Sun S*. Continuous venovenous hemofiltration combined with hemoperfusion for toxic epidermal necrolysis: a retrospective cohort study. J Dermatolog Treat. 2016 :24:1-7. (*通讯作者）

25.Ma F, Liu Y, Bai M, Li Y, Yu Y, Zhou M, Wang P, He L, Huang C, Wang H, Sun S*The Reduction Rate of Serum Sodium and Mortality in Patients Undergoing Continuous Venovenous Hemofiltration for Acute Severe Hypernatremia. Am J Med Sci. 2016 :352(3):272-9. (*通讯作者）

26.He L, Zhao X, Wang H, Zhang P, Guo C, Huang C, Liu X, Yao F, Chen Y, Lou W, Sun S*, Fan D. RUNX3 mediates suppression of tumor growth and metastasis of human CCRCC by regulating cyclin related proteins and TIMP-1.PLoS One. 2012;7(3):e32961. (*通讯作者).

27.Liu M, Ning X, Li R, Yang Z1, Yang X, Sun S*, Qian Q*. Signalling pathways involved in hypoxia-induced renal fibrosis. J Cell Mol Med. 2017 Jul;21(7):1248-1259. (*共同通讯作者).

28.Du R, Sun W, Xia L, Zhao A, Yu Y, Zhao L, Wang H, Huang C*, Sun S*. Hypoxia-induced Down-Regulation of microRNA-34a Promotes EMT by Targeting the Notch Signaling Pathway in Tubular Epithelial Cells. PLoS One. 2012;7(2):e30771. (*通讯作者).

29.Zhang W, Bai M*, Yu Y, Li L, Zhao L, Sun S*, Chen X*. Safety and efficacy of regional citrate anticoagulation for continuous renal replacement therapy in liver failure patients: a systematic review and meta-analysis. Crit Care. 2019 Jan 24;23(1):22. doi: 10.1186/s13054-019-2317-9. (*通讯作者)

30.Liu H, Liu W, Liu S, Meng Q, Zhang N, Wang H, Li R, Wang L, Zhang P*, Sun S *. Reconstitution of kidney side population cells after ischemia-reperfusion injury by self-proliferation and bone marrow-derived cell homing. Evid Based Complement Alternat Med. 2013;2013:370961.（*共同通讯作者）

31.He L, Lou W, Ji L, Liang W, Zhou M, Xu G, Zhao L, Huang C, Li R, Wang H, Chen X*, Sun S*.Serum response factor accelerates the high glucose-induced Epithelial-to-Mesenchymal Transition (EMT) via snail signaling in human peritoneal mesothelial cells.PLoS One. 2014 Oct 10;9(10):e108593.（*共同通讯作者）

32.Ning X#, Sun S#, Zhang K, Liang J, Chuai Y, Li Y, Wang X. S100A6 Protein Negatively Regulates CacyBP/SIP-Mediated Inhibition of Gastric Cancer Cell Proliferation and Tumorigenesis. PLoS One. 2012;7(1):e30185.（#共同第一作者)

33.Huang C*, Du R, Zhang P, Meng H, Jia H, Song Y, Li M, Zhang Y, Sun S*. Expression, purification, and functional characterization of recombinant PTD-SARA. Acta Biochim Biophys Sin (Shanghai). 2011 Feb;43(2):110-7. (*共同通讯作者)

34.X.W. Liu*, D.M. Li, G.S. Xu and S.R. Sun*. Comparison of the therapeutic effects of leflunomide and mycophenolate mofetil for the treatment of immunoglobulin a nephropathy manifesting with nephrotic syndrome. International Journal of Clinical Pharmacology and Therapeutics. 2010 Aug;48(8):509-13.（*共同通讯作者）

35.Ning X#, Sun S#, Hong L, Liang J, Liu L, Han S, Liu Z, Shi Y, Li Y, Gong W, Zhang S, Chen Y, Guo X, Cheng Y, Wu K, Fan D.Calcyclin-binding protein inhibits proliferation, tumorigenicity, and invasion of gastric cancer. Mol Cancer Res. 2007 Dec;5(12):1254-62. (#共同第一作者)

36.Huang C*, Zhang P, Du R, Li Y, Yu Y, Zhou M, Jing R, Li L, Zheng Y, Wang H, Liu H, He L, Sun S*. Treatment of acute hypernatremia in severely burned patients using continuous veno-venous hemofiltration with gradient sodium replacement fluid: a report of nine cases. Intensive Care Med. 2013 Aug;39(8):1495-6.（*共同通讯作者）

37.Zhang X#, Sun S#, Li S, Feng X, Wang S, Liu C, Hang Z, Tong C, Zhu C, Bai B, Xu B, Feng Q, Zhao Q. Early Classic Hemofiltration Exhibits No Benefits in Severe Acute Pancreatitis With Early Organ Failure: A Retrospective Case-Matched Study. Artif Organs. 2014 Apr;38(4):335-41. (#共同第一作者)

38.Huang C*, Zhang P, Liu H, Li Y, Yu Y, Du R, Wang H, Li R, Zhong Y, Li Y, Sun S*.Treatment for acute arsine poisoning with blood purification.Intensive Care Med. 2015 Mar;41(3):549-50. (*共同通讯作者）

39.Bai M*, Zhou M, He L, Ma F, Li Y, Yu Y, Wang P, Li L, Jing R, Zhao L, Sun S*. Citrate versus heparin anticoagulation for continuous renal replacement therapy: an updated meta-analysis of RCTs. Intensive Care Med. 2015;41(12):2098-110.（*共同通讯作者）

40.He L, Che M, Hu J, Li S, Jia Z, Lou W, Li C, Yang J, Sun S*, Wang H*, Chen X. Twist contributes to proliferation and epithelial-to-mesenchymal transition-induced fibrosis by regulating YB-1 in human peritoneal mesothelial cells. Am J Pathol. 2015 Aug;185(8):2181-93.（*共同通讯作者）

41.Li H#, Sun S#, Chen J, Xu G, Wang H, Qian Q.Genetics of Magnesium Disorders. Kidney Dis (Basel). 2017;3(3):85-97. (#共同第一作者)

42.Wang D, Zhou M, Wang Y, Sun S*. Suppression of high-mobility group box 1 ameliorates xerostomia in a sjogren syndrome-triggered mouse model. Can J Physiol Pharmacol. 2020 Jan 14. doi: 10.1139/cjpp-2019-0337.（*通讯作者）

43.Zhao L, Ma F, Yu Y, Li Y, Wang Y, He L, Zhou M, Tian X, Jing R, Li L, Li L, Huang C, Bai M*, Sun S*. Regional Citrate Anticoagulation versus No-Anticoagulation for Continuous Venovenous Hemofiltration in Acute Severe Hypernatremia Patients with Increased Bleeding Risk: A Retrospective Cohort Study. Blood Purif. 2019 Sep 13:1-11. doi: 10.1159/000502937.（*共同通讯作者）

44.Lei W, Wang H, Di W, Feng M, Li L, Shiren S*. Bilateral Primary Renal Lymphoma Presented As Homogenous Renal Enlargement And Acute Interstitial Nephritis. Urol J. 2020 May 16;17(3):317-320. doi: 10.22037/uj.v0i0.4596. PMID: 30882172（*通讯作者）

45.Liu B, Bai M, Wang Y, Wang D, Zhao J, Li L, Dong R, Sun S*. The efficacy and safety of bortezomib-based chemotherapy for immunoglobulin light chain amyloidosis: A systematic review and meta-analysis. Eur J Intern Med. 2019 Nov;69:32-41. doi: 10.1016/j.ejim.2019.08.011.（*通讯作者）

46.He J, Jiang YL, Wang Y, Tian XJ, Sun S*.Micro-vesicles from mesenchymal stem cells overexpressing miR-34a inhibit transforming growth factor-β1-induced epithelial- mesenchymal transition in renal tubular epithelial cells in vitro. Chin Med J (Engl). 2020 Apr 5;133(7):800-807. doi: 10.1097/CM9.0000000000000720.PMID: 32149762（*通讯作者）

47.Ma F, Yang X, Zhou M, Bai M, Zhao L, Li L, Dong R, Liu C, Li R, Sun S*. Treatment for IgA nephropathy with stage 3 or 4 chronic kidney disease: low-dose corticosteroids combined with oral cyclophosphamide. J Nephrol. 2020 May 23. doi: 10.1007/s40620-020-00752-x.（*通讯作者）

48.Wang D, Zhou M, Wang Y, Sun S*.Suppression of High-Mobility Group Box 1 Ameliorates Xerostomia in a Sjögren Syndrome-Triggered Mouse Model. Can J Physiol Pharmacol. 2020 Jun;98(6):351-356. doi: 10.1139/cjpp-2019-0337. Epub 2020 Jan 14.PMID: 31935120（*通讯作者）

49.Yu Y, Bai M, Ma F, Zhang W, Li Y, Zhao L, Li L, Zhou M, Li L, Sun S*.Regional citrate anticoagulation versus no-anticoagulation for continuous venovenous hemofiltration in patients with liver failure and increased bleeding risk:A retrospective case-control study. PLoS One. 2020 May 5;15(5):e0232516.（*通讯作者）

50.Ma F, Liu L, Dong R, Yang X, Wei L, Li L, Bai M, Sun S*.Renal survival and risk factors in IgA nephropathy with crescents.Int Urol Nephrol. 2020 Jun 12. doi: 10.1007/s11255-020-02457-3.（*通讯作者）

近些年来第一负责人主持的课题：

1. Twist通过调控脂肪酸代谢介导慢性缺氧性肾损伤的机制研究,国家自然科学基金面上项，课题编号：No. 81670655)，起止时间：2017/01-2020/12，经费：62万

2. HIF-1/Twist-Bmi1-Snail/E-cadherin通路介导慢性缺氧性肾损伤的机制研究,国家自然科学基金面上项目，课题编号：No.81170670，起止时间：2012/01-2015/12,经费50万。

3. Twist-microRNA-10b信号通路在慢性缺氧导致的肾小管上皮细胞转分化中作用及其机制,国家自然科学基金面上项目，课题编号：No.81070570，起止时间：2011/01-2013/12,经费：32万。

4.钙周期素结合蛋白（cacyBP/SIP)抑制肾细胞癌恶性表型的分子机制,国家自然科学基金面上项目，课题编号：No.30772461，起止时间：2008/01-2010/12,经费：28万。

5.陕西省特支计划科技创新领军人才项目资助，陕西省委组织部，起止时间：2020.6-2025.5，经费：80万

6.肾脏疾病的防治和国产血液净化产品研发及临床应用评价，十二五科技支撑计划分课题，课题编号：2011BAI10B08，起止时间：2011.4-2014.4，经费：50万

7.常见肾小球疾病发病机制及其早期诊断，“973计划”项目子项目，课题编号：2012CB517605，起止时间：2012.1-2016.1，经费：50万。

8.长链非编码RNA MALAT-1在IgA肾病诊断、疗效评价和预后中的作用，陕西省课题重点项目-社会发展领域，课题编号：2017ZDXM-SF-045，起止时间：2017.1.1-2019.12.31，经费：100万

9.转录因子Twist对miR-214-5p的调控促进肾小管上皮细胞转分化的分子机制，陕西省基金重点项目，课题编号：2014JZ007，起止时间：2014.5-2017.5，经费：20万

10.慢性肾脏病的防治策略及应用，西京医院学科助推，课题编号：XJZT18H09，起止时间：2019.1-2023.12，经费：50万

11.粪菌移植治疗难治性IgA和膜性肾病的安全性和有效性,西京医院学科助推，课题编号：XJZT18Z15,起止时间：2019.1-2020.12,经费：20万

科研获奖：

1.慢性肾脏病的防治关键技术及应用，2018年，陕西省科学技术奖一等奖，排名第1。

2.肿瘤血管生成关键因子调控网络及其临床应用，2012年，陕西省科学技术奖一等奖，排名第10。

3.改善腹膜透析患者生存质量的护理策略及应用，2011年，军队医疗成果三等奖，排名第2

4.提高腹膜透析患者生存率和生活质量的措施及其疗效评估，2008年，军队医疗成果三等奖，排名第1

5.危重病症救治中连续血液净化的疗效评估和机制探讨，2006年，军队医疗成果三等奖，排名第6

申报专利：

国家发明专利2项，排名第2。

专利号:ZL201210350193.4，题目:含蛋白转导域的融合多肽突变体及其制备方法。

专利号:ZL201711485065.X，题目：人附睾蛋白4在制备NF-kB激动剂中的应用。

其它荣誉：

荣立个人三等功及集体三等功各1次；陕西省“特支计划”科技创新领军人才，空军高层次科技人才，获军队优秀专业技术干部人才岗位津贴；陕西省健康教育先进个人，陕西省岗位学雷锋标兵，第四军医大学精品课教员，西京医院教学先进个人，西京医院为军服务先进个人，西京医院医德医风先进个人。